Human Sera
Cayman Chemical BromphenIramInmaleate 50mg
An analytical reference standard categorized as a piperazine has been detected as an AAF during anti-doping testing intended for research and forensic applications
Cayman Chemical IsoquercItrosIde 50mg
A synthetic peptide that contains the sequence PVPPR which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2 specifically blocks the interaction of Sos1 with Grb2 preventing an interaction that is essential for Ras activation by receptor tyrosine kinases
Cayman Chemical AmbroxolhydrochlorIde 100mg
A major metabolite of sildenafil formed via oxidative metabolism of sildenafil by CYP3A4 CYP3A5 and CYP3A7
Cayman Chemical E-5- 2-BromovInyluracIl 50mg
A potent inhibitor of ALK (IC50 1 9 nM) that induces concentration-dependent growth inhibition or cytotoxicity of ALK-positive cancer cells inhibits ALK tyrosine phosphorylation in tumor xenografts in mice for more than 12 hours following single oral dosing at 30 mg/kg
Cayman Chemical BarnIdIpInhydrochlorIde 50mg
A potent reversible and selective inhibitor of ALDH1A1 (IC50 40 nM for the human form)
Cayman Chemical TaurochenodeoxycholIc ACD 50mg
An orally available reversible inhibitor of Akt (Ki 11 nM for Akt1) also inhibits PKA and Cdk2 with IC50 values of 16 and 46 nM respectively reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells both in vitro and in vivo
Cayman Chemical 1MethylhIstamInhydroCLOr 100mg
A flavonoid with diverse biological activities inhibits CYP1A1 and CYP1B1 (Kis 89 and 16 nM respectively) prevents AAPH-induced increases in erythrocyte ROS and MDA levels in a concentration-dependent manner reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model at 1 mg/kg twice per day inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in BALF in a mouse model of ovalbumin-induced chronic asthma at 0 5 mg/kg
Cayman Chemical 5-methoxy Tryptophol 100mg
A dual inhibitor of MRP-1 and BCRP maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM effective against both human BCRP and the mouse homolog Bcrp1
Cayman Chemical 5 6dIhydro5FluorouracIl 50mg
An immunosuppressive drug that inhibits DHODH (IC50s 0 134 1 29 and 10 6 UM for human rat and mouse isoforms respectively) inhibits the proliferation of T cells and B cells and the secretion of IL-17 (IC50s 12 9 3 7 and 6 0 UM respectively in human cells)
Cayman Chemical LoxapInsuccInate 50mg
A secoiridoid polyphenol with diverse biological activities inhibits the proliferation of CWR-R1ca PC3 PC-3M and DU145 cells (IC50s 3 59 0 64 1 03 and 5 35 UM respectively) inhibits the growth of L major promastigotes and amastigotes in vitro (IC50s 18 7 and 87 Ug/ml respectively) and reduces lymph node parasite burden in a mouse model of leishmaniasis at 5 mg/kg reduces hippocampal AB levels in a TgSwDI transgenic mouse model of Alzheimers disease at 5 mg/kg decreases serum IL-6 and TNF-a levels and reduces lung cell apoptosis in a chicken model of LPS-induced acute lung injury at 5 mg/kg
Cayman Chemical Mometason Furoate 50mg
A potent cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 0 45 nM) effective in cells blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s 39 and 220 nM respectively)
Cayman Chemical -NornIcotIn 100mg
A natural indole alkaloid with demonstrated beneficial effects in cancer obesity inflammation and many other conditions an AhR antagonist (Ki 28 nM) activator of TRPV1 (EC50 45 nM) and inhibitor of signaling through NF-KB
Cayman Chemical NIlvadIpIn 100mg
A JAK1 and JAK2 inhibitor (IC50s 0 0059 and 0 0057 UM respectively) selective for JAK1 and JAK2 over JAK3 TYK2 c-Met and Chk2 (IC50s 0 4 0 053 10 and 1 UM respectively) inhibits IL-6-induced phosphorylation of STAT3 in isolated human PBMCs and rat whole blood (IC50s 0 044 and 0 128 UM respectively) reduces disease severity in a type II collagen-induced mouse model of arthritis at 3 and 10 mg/kg decreases lung macrophage infiltration and disease severity in rhesus monkeys infected with SARS-CoV-2 at 4 mg/animal
Cayman Chemical TrospIumchlorIde 100mg
A cell-permeable asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 0 8 M) inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest